کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10432529 | 910251 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
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![عکس صفحه اول مقاله: Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses](/preview/png/10432529.png)
چکیده انگلیسی
It has been widely observed that atherosclerotic stenosis occurs at sites with complex hemodynamics, such as arteries with high curvature or bifurcations. These regions usually have very low or highly oscillatory wall shear stress (WSS). In the present study, 3D sinusoidally pulsatile blood flow through the models of internal carotid artery (ICA) with different geometries was investigated with computational simulation. Three preferred sites of stenoses were found along the carotid siphon with low and highly oscillatory WSS. The risk for stenoses at these sites was scaled with the values of time-averaged WSS and oscillating shear index (OSI). The local risk for stenoses at every preferred site of stenoses was found different between 3 types of ICA, indicating that the geometry of the blood vessel plays significant roles in the atherogenesis. Specifically, the large curvature and planarity of the vessel were found to increase the risk for stenoses, because they tend to lower WSS and elevate OSI. Therefore, the geometric study makes it possible to estimate the stenosis location in the ICA siphon as long as the shape of ICA was measured.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 45, Issue 1, 3 January 2012, Pages 83-89
Journal: Journal of Biomechanics - Volume 45, Issue 1, 3 January 2012, Pages 83-89
نویسندگان
Chi Zhang, Sheng Xie, Shuyu Li, Fang Pu, Xiaoyan Deng, Yubo Fan, Deyu Li,