کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10433681 | 910370 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quantitative evaluation of threshold fiber strain that induces reorganization of cytoskeletal actin fiber structure in osteoblastic cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
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چکیده انگلیسی
The cytoskeletal stress fiber structure plays essential roles in various kinds of cellular functions such as shape maintenance, active motility and mechanosensing, and its structure is dynamically reorganized under each functional process. In known reorganization mechanisms of the stress fibers, a change in its mechanical condition has been suggested as one of the key mediators that affect the reorganization process. Some experimental studies have clarified that tension release in the stress fibers induces fiber depolymerization that is considered to be the initial phase of the reorganization process. However, quantitative mechanical values such as strain or stress that induce depolymerization have still not been evaluated. This study is aimed at the quantitative evaluation of the mechanical value that induces stress fiber depolymerization, to gain a basic understanding of the reorganization phenomenon from a mechanical viewpoint. Osteoblastic cells (MC3T3-E1) were cultured on prestretched silicone rubber substrate. Compressive deformation was applied to the cells by uniaxially releasing the prestretched substrate strain and change in the stress fiber structure was observed. The results indicated that the compressive strain magnitude, not in the whole cell body but in the stress fiber itself, is important to induce disassembly of the stress fiber structure. The existence of a threshold strain magnitude for initiating fiber disassembly was also suggested; the threshold strain magnitude was evaluated as approximately â0.20.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 38, Issue 9, September 2005, Pages 1895-1901
Journal: Journal of Biomechanics - Volume 38, Issue 9, September 2005, Pages 1895-1901
نویسندگان
Katsuya Sato, Taiji Adachi, Mamoru Matsuo, Yoshihiro Tomita,