کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10444611 | 916119 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extinction of drug cue reactivity in methamphetamine-dependent individuals
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Extinction of drug cue reactivity in methamphetamine-dependent individuals Extinction of drug cue reactivity in methamphetamine-dependent individuals](/preview/png/10444611.png)
چکیده انگلیسی
Conditioned responses to drug-related environmental cues (such as craving) play a critical role in relapse to drug use. Animal models demonstrate that repeated exposure to drug-associated cues in the absence of drug administration leads to the extinction of conditioned responses, but the few existing clinical trials focused on extinction of conditioned responses to drug-related cues in drug-dependent individuals show equivocal results. The current study examined drug-related cue reactivity and response extinction in a laboratory setting in methamphetamine-dependent individuals. Methamphetamine cue-elicited craving was extinguished during two sessions of repeated (3) within-session exposures to multi-modal (picture, video, and in-vivo) cues, with no evidence of spontaneous recovery between sessions. A trend was noted for a greater attenuation of response in participants with longer (4-7 day) inter-session intervals. These results indicate that extinction of drug cue conditioned responding occurs in methamphetamine-dependent individuals, offering promise for the development of extinction- based treatment strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behaviour Research and Therapy - Volume 48, Issue 9, September 2010, Pages 860-865
Journal: Behaviour Research and Therapy - Volume 48, Issue 9, September 2010, Pages 860-865
نویسندگان
Kimber L. Price, Michael E. Saladin, Nathaniel L. Baker, Bryan K. Tolliver, Stacia M. DeSantis, Aimee L. McRae-Clark, Kathleen T. Brady,