Sleep disturbances and depressed mood: A harmful combination associated with increased leptin levels in women with normal weight

► No association between depressed mood or sleep disturbances alone and leptin levels. ► Elevated leptin levels in depressed normal-weight women with sleep disturbances. ► Modification of leptin-depressed-mood-sleep-disturbances relationship by overweight. ► No association between any combination of depressed mood and sleep disturbances in men.