The functional connectivity between amygdala and extrastriate visual cortex activity during emotional picture processing depends on stimulus novelty

▶ Emotional modulation of the amygdala decreases with repeated picture presentation. ▶ Emotional modulation of the inferior temporal cortex (ITC) hardly habituates. ▶ Amygdala and ITC are correlated only during viewing novel emotional stimuli. ▶ The amygdala seems to trigger increased ITC activation to novel emotional stimuli.