کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10509944 | 949445 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboons
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboons Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboons](/preview/png/10509944.png)
چکیده انگلیسی
Patients in methadone maintenance programs use benzodiazepines to “boost” methadone's subjective effects, and flunitrazepam has been prominent in this context. Self-administration of flunitrazepam (0.001-0.32Â mg/kg i.v.) alone and during daily oral methadone administration was evaluated in three baboons. Flunitrazepam maintained self-injection as an inverted U-shaped function of dose at rates higher than those maintained by most other benzodiazepines under the same procedure. In the context of demonstrated physical dependence on 3.2Â mg/kg/day p.o. methadone, flunitrazepam doses on the ascending limb of the dose-effect curve maintained greater rates of self-injection than before methadone in two baboons. When the methadone dose decreased to 1.8Â mg/kg/day, self-injection remained higher for those baboons and became higher than before methadone for the third baboon. Self-injection remained higher when methadone decreased to 1.0Â mg/kg/day, except self-injection of the lowest flunitrazepam dose returned to or below the pre-methadone rate for two baboons. After methadone was discontinued, the dose-effect curve shifted to the right in one baboon but remained to the left in two. Flunitrazepam thus served as a reinforcer alone and in the context of methadone maintenance. Lower doses maintained higher self-injection during and shortly after methadone maintenance. Further research should explore the duration of higher self-injection rates following methadone maintenance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 78, Issue 2, 9 May 2005, Pages 113-123
Journal: Drug and Alcohol Dependence - Volume 78, Issue 2, 9 May 2005, Pages 113-123
نویسندگان
Nancy A. Ator, Roland R. Griffiths, Elise M. Weerts,