کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10529 689 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mesoporous carbide-derived carbon with porosity tuned for efficient adsorption of cytokines
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Mesoporous carbide-derived carbon with porosity tuned for efficient adsorption of cytokines
چکیده انگلیسی

Porous carbons can be used for the purification of various bio-fluids, including the cleansing blood of inflammatory mediators in conditions such as sepsis or auto-immune diseases. Here we show that the control of pore size in carbons is a key factor to achieving efficient removal of cytokines. In particular, the surface area accessible by the protein governs the rate and effectiveness of the adsorption process. We demonstrate that novel mesoporous carbon materials synthesized from ternary MAX-phase carbides can be optimized for efficient adsorption of large inflammatory proteins. The synthesized carbons, having tunable pore size with a large volume of slit-shaped mesopores, outperformed all other materials or methods in terms of efficiency of TNF-α removal and the results are comparable only with highly specific antibody–antigen interactions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 27, Issue 34, December 2006, Pages 5755–5762
نویسندگان
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