کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10533125 961849 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacokinetics of ciprofloxacin in eels by high-performance liquid chromatography with fluorescence detection
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Pharmacokinetics of ciprofloxacin in eels by high-performance liquid chromatography with fluorescence detection
چکیده انگلیسی
The plasma kinetics of ciprofloxacin (CF) were investigated in the eels after administration by oral gavage and bath treatment. Plasma concentrations of CF were determined by high-performance liquid chromatography with fluorescence detection. The mean concentration time data after oral gavage of a single dose (10.0 mg/kg CF) and after bath treatment by exposure (10 μg/ml CF) to medicated water for 48 h were both best fitted by a one-compartment model. After oral gavage in eels, the half-time of absorption (T1/2Ka) was 0.10 h, the half-time of elimination (T1/2Ke) was 51.87 h, and the maximum plasma concentration (Cmax) was 0.4552 μg/ml at Tmax 0.88 h. After bath treatment, the T1/2Ka was 0.02 h, the T1/2Ke was 15.46 h, and the Cmax was 0.1175 μg/mL at Tmax 0.22 h.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytical Biochemistry - Volume 341, Issue 2, 15 June 2005, Pages 275-279
نویسندگان
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