کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10553 690 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The angiogenic potential of three-dimensional open porous synthetic matrix materials
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
The angiogenic potential of three-dimensional open porous synthetic matrix materials
چکیده انگلیسی

Angiogenesis is a complex multistage process involving multiple factors and numerous cells. The use of the Chorioallantoic Membrane (CAM) assay is well documented as a method to investigate angiogenesis. This technique is ideal for screening samples, but requires an objective analysis technique. The angiogenic response of vascular endothelial growth factor (VEGF) was used to confirm that computer-based image analysis was able to quantify angiogenesis. Image analysis was used on samples of increasing porosity of PLLA to determine the effect of pore size on angiogenesis. Another effect also noted was that of an inflammatory response co-incident with angiogenesis. The difference in pore size made a difference to both angiogenesis and inflammation. Real-time polymerase chain reaction (PCR) was used with primers for TNF-α to demonstrate and measure the presence of an inflammatory response.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 28, Issue 25, September 2007, Pages 3679–3686
نویسندگان
, , , ,