کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10557170 | 968491 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of moxifloxacin in tablets and human urine by square-wave adsorptive voltammetry
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This work presents an electroanalytical methodology developed for square-wave voltammetry based in the electrochemical reduction in hanging mercury drop electrode (HMDE), which is simple, fast, reliable and sensitive for determination of moxifloxacin (MOXI) in tablets and spiked urine human samples. The support electrolyte that provided a more defined and intense peak current for MOXI determination was the phosphate buffer 0.04 mol lâ 1 pH 8.0. In the best-optimized conditions the drug presented an only peak of reduction at â 1.38 V vs. Ag/AgCl, using an Eacc. of â 0.30 V. An LOD of 0.44 and 3.20 ng mlâ 1 and an LOQ of 1.46 and 10.60 ng mlâ 1 were found for the pure standard of moxifloxacin and in the presence of matrix, respectively. A good recovery was obtained for assay spiked urine samples and a good quantification of MOXI was achieved in a commercial formulation. The methodology proposed was more sensitive than the spectrofluorimetric and spectrophotometric method with precision and accuracy equivalent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microchemical Journal - Volume 81, Issue 2, October 2005, Pages 209-216
Journal: Microchemical Journal - Volume 81, Issue 2, October 2005, Pages 209-216
نویسندگان
Magno Aparecido G. Trindade, Glaucia Maria da Silva, Valdir Souza Ferreira,