کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10572696 976006 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A facile procedure for synthesis of 3-[2-(N,N-dialkylamino)ethyl]-3-fluorooxindoles by direct fluorination of N,N-dialkyltryptamines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
A facile procedure for synthesis of 3-[2-(N,N-dialkylamino)ethyl]-3-fluorooxindoles by direct fluorination of N,N-dialkyltryptamines
چکیده انگلیسی
▶ One-step synthesis of 3-fluorooxindoles from indoles having basic amine moieties ▶ Selectfluor™ was used for the fluorination ▶ A Lewis acid as an additive significantly enhanced yields of 3-fluorooxindoles ▶ The Lewis acid decreased the nucleophilicity of the amino group ▶ The developed procedure could apply to an antimigraine drug, rizatriptan.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 132, Issue 3, March 2011, Pages 181-185
نویسندگان
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