Efficient synthesis of α-(fluoro/chloro/methoxy)disulfonylmethane derivatives as tunable substituted methyl synthons via a new C-S bond forming strategy

A new synthetic protocol for the preparation of α-fluoro(disulfonyl)methane and its chloro as well as methoxy analogues has been developed. Due to the synthetic utility of α-fluoro(bisphenylsulfonyl)methane (FBSM) as a versatile synthon in the preparation of various useful fluoromethylated organic molecules, search for an easy and economic for its preparation route has been essential. The C-S bond forming strategy is utilized in this new synthetic approach, which can be applied to a variety of substrates with high efficiency and selectivity.