کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10630944 | 991464 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair
ترجمه فارسی عنوان
توسعه و مشخصه لیتیوم آزاد سیلیکات عینک زیست فعال و داربست های آنها برای تعمیر استخوان
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سرامیک و کامپوزیت
چکیده انگلیسی
Incorporation of therapeutic ions into the structure of bioactive glasses for direct stimulation of cells is a very attractive approach for tissue engineering strategies. Lithium has recently been identified as a biologically active ion which can stimulate osteoblast cell activity. In this study, lithium-containing bioactive glasses (Li-BGs) where Li2O substitutes Na2O in different amounts (2.5, 5 and 10Â wt.% Li2O) in 45S5 bioactive glass (BG) were produced and made into 3D scaffolds by the foam replica method. The structural changes that occur after heat treatment, the effect of lithium-content on the bioactivity of the glasses and their lithium ion release profiles were investigated. The results show that the novel Li-BG formulations exhibit the formation of an apatite-like layer on their surface after immersion in SBF for 1Â day thus confirming their high surface reactivity, similar to undoped 45S5 BG. XRD results showed that the Li-doped BGs crystallize mainly to combeite (Na2Ca2Si3O9) and silicorhenanite (SiO4(PO4)2Ca5) but also Li6P6O18 and Li3PO4 phases were detected. In terms of lithium ion release, the formulations at 2.5Â wt.% and 5Â wt.% Li2O content were the only ones to be within the therapeutic range (<Â 8.3Â ppm).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Non-Crystalline Solids - Volume 432, Part A, 15 January 2016, Pages 65-72
Journal: Journal of Non-Crystalline Solids - Volume 432, Part A, 15 January 2016, Pages 65-72
نویسندگان
V. Miguez-Pacheco, T. Büttner, A.L.B. Maçon, J.R. Jones, T. Fey, D. de Ligny, P. Greil, J. Chevalier, A. Malchere, A.R. Boccaccini,