کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10637 695 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A biomimetic peptide fluorosurfactant polymer for endothelialization of ePTFE with limited platelet adhesion
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
A biomimetic peptide fluorosurfactant polymer for endothelialization of ePTFE with limited platelet adhesion
چکیده انگلیسی

Endothelialization of expanded polytetrafluoroethylene (ePTFE) has the potential to improve long-term patency for small-diameter vascular grafts. Successful endothelialization requires ePTFE surface modification to permit cell attachment to this otherwise non-adhesive substrate. We report here on a peptide fluorosurfactant polymer (FSP) biomimetic construct that promotes endothelial cell (EC)-selective attachment, growth, shear stability, and function on ePTFE. The peptide FSP consists of a flexible poly(vinyl amine) backbone with EC-selective peptide ligands for specific cell adhesion and pendant fluorocarbon branches for stable anchorage to underlying ePTFE. The EC-selective peptide (primary sequence: Cys–Arg–Arg–Glu–Thr–Ala–Trp–Ala–Cys, CRRETAWAC) has demonstrated high binding affinity for the α5β1 integrin found on ECs. Here, we demonstrate low affinity of CRRETAWAC for platelets and platelet integrins, thus providing it with EC-selectivity. This EC-selectivity could potentially facilitate rapid in vivo endothelialization and healing without thrombosis for small-diameter ePTFE vascular grafts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 28, Issue 24, August 2007, Pages 3537–3548
نویسندگان
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