کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1067807 | 948927 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The effect of cannabinoid CB1 receptor antagonist rimonabant (SR-141716) on ethanol drinking in high-preferring rats The effect of cannabinoid CB1 receptor antagonist rimonabant (SR-141716) on ethanol drinking in high-preferring rats](/preview/png/1067807.png)
The present study investigated the effect of the cannabinoid CB1 receptor antagonist, rimonabant (SR-141716) on ethanol intake in selectively bred alcohol-preferring Warsaw High-Preferring rats. Ethanol (10% vol/vol) and food were available in daily 4-h limited access period while water was available ad libitum. The administration (i.p.) of single 2.5 and 5.0-mg/kg doses of rimonabant preferentially reduced ethanol intake, whereas a 10 mg/kg dose of rimonabant similarly reduced both ethanol and food intake. Our result extends the suppressive effect of cannabinoid CB1 receptor antagonist to the ethanol drinking behavior in Warsaw High-Preferring line of rats. The result also supports a growing body of literature indicating that the cannabinoid CB1 receptor is involved in motivational and appetitive properties of ethanol.
Journal: Alcohol - Volume 42, Issue 6, September 2008, Pages 509–512