کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10690454 | 1019252 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Subharmonic aided pressure estimation for monitoring interstitial fluid pressure in tumours - In vitro and in vivo proof of concept
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Subharmonic aided pressure estimation for monitoring interstitial fluid pressure in tumours - In vitro and in vivo proof of concept Subharmonic aided pressure estimation for monitoring interstitial fluid pressure in tumours - In vitro and in vivo proof of concept](/preview/png/10690454.png)
چکیده انگلیسی
The feasibility of using subharmonic aided pressure estimation (SHAPE) to noninvasively estimate interstitial fluid pressure (IFP) was studied. In vitro, radiofrequency signals, from 0.2 ml/l of Definity (Lantheus Medical Imaging, N Billerica, MA) were acquired within a water-tank with a Sonix RP ultrasound scanner (Analogic Ultrasound, Richmond, BC, Canada; fT/R = 6.7/3.35 MHz and fT/R = 10/5 MHz) and the subharmonic amplitudes of the signals were compared over 0-50 mmHg. In vivo, five swine with naturally occurring melanomas were studied. Subharmonic signals were acquired from tumours and surrounding tissue during infusion of Definity and compared to needle-based pressure measurements. Both in vitro and in vivo, an inverse linear relationship between hydrostatic pressure and subharmonic amplitude was observed with r2 = 0.63-0.95; p < 0.05, maximum amplitude drop 11.36 dB at 10 MHz and â8 dB, and r2 as high as 0.97; p < 0.02 (10 MHz and â4/â8 dB most promising), respectively, indicating that SHAPE may be useful in monitoring IFP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasonics - Volume 54, Issue 7, September 2014, Pages 1938-1944
Journal: Ultrasonics - Volume 54, Issue 7, September 2014, Pages 1938-1944
نویسندگان
V.G. Halldorsdottir, J.K. Dave, J.R. Eisenbrey, P. Machado, H. Zhao, J.B. Liu, D.A. Merton, F. Forsberg,