Simulations of adaptive temperature control with self-focused hyperthermia system for tumor treatment

►We present a technique to control the temperature distribution and the temperature elevation in hyperthermia interest. ► An optimal control theory based on a state-space model is used for control of tissue temperature with a SISO controller. ► The technique has better adaptive ability for variable parameters. ► The temperature and temperature elevation can be achieved at the desired time. ►The control technique can improve the curative effect and decrease the treatment time for heating large tumor.