کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1070294 | 1486177 | 2011 | 8 صفحه PDF | دانلود رایگان |

ObjectiveTo determine if directly observed antiretroviral therapy (DOT) is more efficacious than self-administered therapy for improving adherence and reducing HIV viral load (VL) among methadone-maintained opioid users.DesignTwo-group randomized trial.SettingTwelve methadone maintenance clinics with on-site HIV care in the Bronx, New York.ParticipantsHIV-infected adults prescribed combination antiretroviral therapy.Main outcomes measuresBetween group differences at four assessment points from baseline to week 24 in: (1) antiretroviral adherence measured by pill count, (2) VL, and (3) proportion with undetectable VL (<75 copies/ml).ResultsBetween June 2004 and August 2007, we enrolled 77 participants. Adherence in the DOT group was higher than in the control group at all post-baseline assessment points; by week 24 mean DOT adherence was 86% compared to 56% in the control group (p < 0.0001). Group differences in mean adherence remained significant after stratifying by baseline VL (detectable versus undetectable). In addition, during the 24-week intervention, the proportion of DOT participants with undetectable VL increased from 51% to 71%.ConclusionsAmong HIV-infected opioid users, antiretroviral DOT administered in methadone clinics was efficacious for improving adherence and decreasing VL, and these improvements were maintained over a 24-week period. DOT should be more widely available to methadone patients.
Journal: Drug and Alcohol Dependence - Volume 113, Issues 2–3, 15 January 2011, Pages 192–199