کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1070605 1486180 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Social influences on morphine sensitization in adolescent females
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Social influences on morphine sensitization in adolescent females
چکیده انگلیسی

We recently observed that social interactions influence morphine responsiveness in adolescent males. Given sex-related differences in both social interactions and responses to morphine, the present study examines social influences on morphine sensitization in adolescent female mice. Four experimental groups were examined: (1) morphine-treated mice (twice daily, 10–40 mg/kg, s.c.) housed physically and visually separated from saline-treated mice (‘morphine only’), (2) morphine-treated mice housed together with saline-treated mice (‘morphine cage-mates (of saline)’), (3) saline-treated mice housed together with morphine-treated mice (‘saline cage-mates (of morphine)’), and (4) saline-treated mice housed physically and visually separated from morphine-treated mice (‘saline only’). Following the treatment period, mice were tested individually for their locomotor response to 20 mg/kg morphine (s.c.). There were no significant differences in morphine-induced hyper-locomotion between saline only and saline cage-mates (of morphine) female adolescent mice. Notably, morphine only mice exhibited significantly greater morphine sensitization as compared to morphine cage-mates (of saline). Thus, this study demonstrates social influences on morphine sensitization in adolescent females. Drug use during early adolescence is a key predictor of later drug abuse and dependence during adulthood. Thus, understanding the specific vulnerabilities to drug use in this age group may represent a first step in helping develop more effective treatment programs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 110, Issue 3, 1 August 2010, Pages 263–266
نویسندگان
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