کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10706800 | 1023506 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential biological responses of green tea polyphenol in normal cells vs. cancer cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential biological responses of green tea polyphenol in normal cells vs. cancer cells Differential biological responses of green tea polyphenol in normal cells vs. cancer cells](/preview/png/10706800.png)
چکیده انگلیسی
Green tea has shown remarkable anti-inflammatory and cancer chemopreventive effects in many animal tumor bioassays, cell culture systems and epidemiological studies. Many of these biological effects of green tea are mediated by epigallocatechin 3-gallate, the major polyphenol present therein. In this study, the differential biological responses of green tea polyphenols (GTP) were examined in normal rat osteoblasts (NRO) vs. human osteosarcoma (MG-63 and Saos-2) cells. The GTP treatment with micromolar concentrations (0.1, 1, 10 and 100 μM for 24 h) resulted in dose-dependent inhibitions of cell growth and alkaline phosphatase activity, morphological alterations, G0/G1-phase arrest of the cell cycle and induction of apoptosis in both osteosarcoma cells, but not in the NRO. These results suggest that the GTP treatment may be contributed to the differential regulation of cell cycle in normal cells and cancer cells, which can be exploited to craft strategies for the physiological preservation of cells or tissues by GTP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Applied Physics - Volume 5, Issue 5, July 2005, Pages 449-452
Journal: Current Applied Physics - Volume 5, Issue 5, July 2005, Pages 449-452
نویسندگان
Han-Ki Park, Dong-Wook Han, Young Hwan Park, Jong-Chul Park,