Magnetic nanoparticles for high-sensitivity detection on nucleic acids via superconducting-quantum-interference-device-based immunomagnetic reduction assay

►The feasibility of assaying DNA molecules utilizing immunomagnetic reduction (IMR) is investigated. ►The sensitivity of the SQUID-based IMR was 0.03 fmol or 1.6 pM. ►It is also demostrated that SQUID-based IMR is able for the detection of single-nucleotidepolymorphism.