کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1071091 1486204 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems
چکیده انگلیسی

Several studies have demonstrated a significant association between the A1 allele of the TaqIA polymorphism and various phenotypes of alcoholism, others have not, and two studies have shown the reversed association, where the A2 allele was associated with higher levels of alcohol consumption. We sought to test for an association between early onset (in childhood or adolescence) alcohol use disorders and the DRD2 TaqIA polymorphism and to resolve some of the hypothesized explanations for previous negative results, utilizing a larger sample than many previous studies.MethodsWe selected individuals with a lifetime alcohol abuse or dependence (n = 239) diagnosis from a clinically ascertained sample of youth (ages 13–19) with serious conduct and substance problems (about 90% also met criteria for conduct disorder and a cannabis use disorder) and compared them with individuals without a lifetime alcohol use disorder diagnosis ascertained from (1) community adolescent controls (n = 151), (2) siblings of patients (n = 87) and (3) other adolescent patients (n = 92). Cases were compared with each control group, separately, by genotype using the χ2-test. Using 78 adolescent patients with an alcohol use disorder where genotypic information was available for both parents, we conducted the transmission disequilibrium test (TDT).ResultsCase–control results were non-significant using the entire community control sample (χ22=1.92; p = 0.38) and when restricting the sample to Caucasians (χ22=3.81; p = 0.15) or Hispanics (χ22=1.70; p = 0.43). Case–control results using the other comparison groups and TDT results were also non-significant.DiscussionWe did not find support for an association between the TaqIA polymorphism and early onset alcohol use disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 88, Issues 2–3, 11 May 2007, Pages 130–137
نویسندگان
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