کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10712574 | 1025204 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemical exchange saturation transfer MR imaging of articular cartilage glycosaminoglycans at 3Â T: Accuracy of B0 Field Inhomogeneity corrections with gradient echo method
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کلمات کلیدی
CESTNSATSEROIFOVGAGAPTSNRIRBKnee osteoarthritis - استئوآرتریت زانوOsteoarthritis - استئوآرتریت(آرتروز)MRI - امآرآی یا تصویرسازی تشدید مغناطیسیChemical exchange saturation transfer - انتقال اشباع تبادل شیمیاییMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیturbo spin echo - توربو اسپین اکوSENSE - حسادتsensitivity encoding - رمزگذاری حساسیتregion of interest - منطقه مورد نظرField of view - میدان دیدsignal to noise ratio - نسبت سیگنال به نویزinstitutional review board - هیئت بررسی نظارتGlycosaminoglycan - گلیکوزآمینوگلیکان
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) is an important molecular MRI methodology developed to assess changes in cartilage GAG concentrations. The correction for B0 field inhomogeneity is technically crucial in gagCEST imaging. This study evaluates the accuracy of the B0 estimation determined by the dual gradient echo method and the effect on gagCEST measurements. The results were compared with those from the commonly used z-spectrum method. Eleven knee patients and three healthy volunteers were scanned. Dual gradient echo B0 maps with different âTE values (1, 2, 4, 8, and 10 ms) were acquired. The asymmetry of the magnetization transfer ratio at 1 ppm offset referred to the bulk water frequency, MTRasym(1 ppm), was used to quantify cartilage GAG levels. The B0 shifts for all knee patients using the z-spectrum and dual gradient echo methods are strongly correlated for all âTE values used (r = 0.997 to 0.786, corresponding to âTE = 10 to 1 ms). The corrected MTRasym(1 ppm) values using the z-spectrum method (1.34% ± 0.74%) highly agree only with those using the dual gradient echo methods with âTE = 10 ms (1.72% ± 0.80%; r = 0.924) and 8 ms (1.50% ± 0.82%; r = 0.712). The dual gradient echo method with longer âTE values (more than 8 ms) has an excellent correlation with the z-spectrum method for gagCEST imaging at 3 T.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 32, Issue 1, January 2014, Pages 41-47
Journal: Magnetic Resonance Imaging - Volume 32, Issue 1, January 2014, Pages 41-47
نویسندگان
Wenbo Wei, Guang Jia, David Flanigan, Jinyuan Zhou, Michael V. Knopp,