کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10712601 | 1025211 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Manganese-enhanced magnetic resonance imaging investigation of the interferon-α model of depression in rats
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
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چکیده انگلیسی
Behavioural tests showed alterations in freezing and struggling parameters, as expected in an experimental model of sickness behaviour. MRI showed a well defined brain region, mainly contained in the visual cortex, in which Mn uptake was significantly lower in treated than in control animals, indicating probably altered functionality. No significant difference was detected in other brain regions. In addition, a statistically significant decrease in the volume of the pituitary gland, paralleled by a slight increase in its Mn content, was detected in treated animals. MEMRI provides both morphological and functional information in the brain of small laboratory animals and can constitute a valuable tool in the investigation of experimental models of psychiatric diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 32, Issue 5, June 2014, Pages 529-534
Journal: Magnetic Resonance Imaging - Volume 32, Issue 5, June 2014, Pages 529-534
نویسندگان
Alessandro Daducci, Stefano Tambalo, Silvia Fiorini, Francesco Osculati, Manuela Teti, Paolo F. Fabene, Mauro Corsi, Angelo Bifone, Andrea Sbarbati, Pasquina Marzola,