کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10712797 | 1025268 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduction of breast density following tamoxifen treatment evaluated by 3-D MRI: preliminary study
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study analyzed the change in breast density in women receiving tamoxifen treatment using 3-D MRI. Sixteen women were studied. Each woman received breast MRI before and after tamoxifen. The breast and the fibroglandular tissue were segmented using a computer-assisted algorithm, based on T1-weighted images. The fibroglandular tissue volume (FV) and breast volume (BV) were measured and the ratio was calculated as the percent breast density (%BD). The changes in breast volume (ÎBV), fibroglandular tissue volume (ÎFV) and percent density (Î%BD) between two MRI studies were analyzed and correlated with treatment duration and baseline breast density. The ÎFV showed a reduction in all 16 women. The Î%BD showed a mean reduction of 5.8%. The reduction of FV was significantly correlated with baseline FV (P<.001) and treatment duration (P=.03). The percentage change in FV was correlated with duration (P=.049). The reduction in %BD was positively correlated with baseline %BD (P=.02). Women with higher baseline %BD showed more reduction of %BD. Three-dimensional MRI may be useful for the measurement of the small changes of ÎFV and Î%BD after tamoxifen. These changes can potentially be used to correlate with the future reduction of cancer risk.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 29, Issue 1, January 2011, Pages 91-98
Journal: Magnetic Resonance Imaging - Volume 29, Issue 1, January 2011, Pages 91-98
نویسندگان
Jeon-Hor Chen, Yeun-Chung Chang, Daniel Chang, Yi-Ting Wang, Ke Nie, Ruey-Feng Chang, Orhan Nalcioglu, Chiun-Sheng Huang, Min-Ying Su,