Correlation of proton MR spectroscopy and diffusion tensor imaging

The spatial distributions of choline and N-acetylaspartate (NAA) correlated to mean fractional anisotropy and apparent diffusion coefficient (ADC) for the inner 6×6=36 voxels defined in MRS, most notably NAA and ADC value (r=−.70, P<.00001; correlation across four subjects, 144 data pairs). This is the first association of neuron metabolite contents in volunteers with structure as indicated by DTI.