کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1071303 1645249 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Management of neonatal abstinence syndrome in neonates born to opioid maintained women
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Management of neonatal abstinence syndrome in neonates born to opioid maintained women
چکیده انگلیسی

Neonates born to opioid-maintained mothers are at risk of developing neonatal abstinence syndrome (NAS), which often requires pharmacological treatment. This study examined the effect of opioid maintenance treatment on the incidence and timing of NAS, and compared two different NAS treatments (phenobarbital versus morphine hydrochloride).Fifty-three neonates born to opioid-maintained mothers were included in this study. The mothers received methadone (n = 22), slow-release oral morphine (n = 17) or buprenorphine (n = 14) throughout pregnancy. Irrespective of maintenance treatment, all neonates showed APGAR scores comparable to infants of non-opioid dependent mothers. No difference was found between the three maintenance groups regarding neonatal weight, length or head circumference. Sixty percent (n = 32) of neonates required treatment for NAS [68% in the methadone-maintained group (n = 15), 82% in the morphine-maintained group (n = 14), and 21% in the buprenorphine-maintained group (n = 3)]. The mean duration from birth to requirement of NAS treatment was 33 h for the morphine-maintained group, 34 h for the buprenorphine-maintained group and 58 h for the methadone-maintained group.In neonates requiring NAS treatment, those receiving morphine required a significantly shorter mean duration of treatment (9.9 days) versus those treated with phenobarbital (17.7 days). Results suggest that morphine hydrochloride is preferable for neonates suffering NAS due to opioid withdrawal.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 87, Issues 2–3, 16 March 2007, Pages 131–138
نویسندگان
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