کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1071463 949403 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bupropion SR for the treatment of smokeless tobacco use
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Bupropion SR for the treatment of smokeless tobacco use
چکیده انگلیسی

BackgroundNo pharmacotherapies have been shown to increase long-term (≥6 months) tobacco abstinence rates among smokeless tobacco (ST) users. Bupropion SR has demonstrated potential efficacy for ST users in pilot studies. We conducted a multicenter, randomized, double-blind, placebo-controlled, clinical trial to assess the efficacy and safety of bupropion SR for tobacco abstinence among ST users.MethodsAdult ST users were randomized to bupropion SR titrated to 150 mg twice daily (N = 113) or placebo (N = 112) for 12 weeks plus behavioral intervention. The primary endpoint was the 7-day point-prevalence tobacco abstinence rate at week 12. Secondary outcomes included prolonged and continuous tobacco abstinence rates, craving and nicotine withdrawal, and weight gain.ResultsThe 7-day point-prevalence tobacco abstinence rates did not differ between bupropion SR and placebo at the end treatment (53.1% versus 46.4%; odds ratio (OR) 1.3; p = 0.301). The 7-day point-prevalence abstinence did not differ at weeks 24 and 52. The prolonged and continuous tobacco abstinence rates did not differ at weeks 12, 24, and 52. A time-by-treatment interaction was observed in craving over time with greater decreases in the bupropion SR group. At 12 weeks, the mean (±S.D.) weight change from baseline among abstinent subjects was an increase of 1.7 (±2.9) kg for the bupropion SR group compared to 3.2 (±2.7) kg for placebo (p = 0.005).ConclusionsBupropion SR did not significantly increase tobacco abstinence rates among ST users, but it significantly decreased craving and weight gain over the treatment period.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 90, Issue 1, 6 September 2007, Pages 56–63
نویسندگان
, , , , , , ,