کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1071802 949428 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Double-blind, placebo-controlled trial of selegiline transdermal system (STS) for the treatment of cocaine dependence
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Double-blind, placebo-controlled trial of selegiline transdermal system (STS) for the treatment of cocaine dependence
چکیده انگلیسی

BackgroundCocaine dependence is a major public health problem for which there is no FDA-approved pharmacological treatment. Selegiline is an irreversible selective inhibitor of monoamine oxidase type B (MAO-B) which may affect cocaine addiction through several potential mechanisms. In this study, selegiline transdermal system (STS) was compared to placebo as a treatment for cocaine dependence. This multi-site, double-blind trial of 300 subjects with cocaine dependence assessed the efficacy of selegiline using subject self-reported cocaine use substantiated by urine benzoylecgonine (BE) as the primary outcome measure. Analysis of the data did not show a significant effect for selegiline over placebo. This study does not support a role for selegiline in treating cocaine dependence. The contrast of this result to earlier, promising preclinical and human pilot data could be due to factors associated with sample size, patient characteristics, dose, or poor predictive validity of preclinical models.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 85, Issue 3, 1 December 2006, Pages 191–197
نویسندگان
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