Protein synthesis as an integral quality control mechanism during ageing

- mRNA translation is mainly regulated at the initiation phase and influences ageing.
- Non-coding RNAs and RNA binding proteins control and fine-tune mRNA homeostasis.
- Intrinsic RNA properties are altered during ageing.
- Protein synthesis is regulated by key pathways that modulate ageing, such as the insulin/IGF and TOR signalling cascades.