Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

► Polyphenols act non-specifically as antioxidants. ► Some polyphenols have anti-acetycholine/butyrylcholinesterase activity. ► Polyphenols protect neurons against NMDA neurotoxicity. ► Polyphenols affect amyloidogenic pathway. ► There are potential barricades in translating polyphenol research into routine clinical application.