کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10736943 1046278 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders
چکیده انگلیسی
The morbidity of ocular diseases, including macular degeneration, diabetic retinopathy, and dry eye disease, has been gradually increasing worldwide. Because these diseases develop from age-associated ocular dysfunctions, interventions against the aging process itself may be a promising strategy for their management. Among the several approaches to interrupt aging processes, calorie restriction (CR) has been shown to recover and/or slow age-related functional declines in various organs, including the eye. Here, we review interventions against the aging process as potential therapeutic approaches to age-related ocular diseases. The effects of CR and CR mimetics in animal models of age-related eye diseases are explored. Furthermore, we discuss the possibilities of expanding this research to prospective studies to elucidate the molecular mechanisms by which CR and/or CR mimetics preserve ocular functions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 48, Issue 10, October 2013, Pages 1096-1100
نویسندگان
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