کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1906088 1534858 2016 6 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effect of polyphenols on presbycusis via oxidative/nitrosative stress suppression in rats
ترجمه فارسی عنوان
اثر محافظتی پلی فنول‌ها بر روی presbycusis از طریق سرکوب استرس اکسیداتیو/نیتروژنیک در موش صحرایی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
سفارش ترجمه تخصصی
با تضمین قیمت و کیفیت
کلمات کلیدی
AHL، از دست دادن شنوایی مرتبط با سن؛ ASSR، پاسخ های ایستا در حالت شنوایی؛ DHE، دی هیدروتیدیم؛ GPx، گلوتاتیون پراکسیداز؛ ROS، گونه های اکسیژن واکنشی RNS، گونه های نیتروژن واکنشی؛ SOD، سوپر اکسید دیسموتاز پلی اتیلن؛ Presbycusis؛ شنوایی پایدار
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Rats of different ages (young and old) are treated with a mixture of polyphenols with antioxidant activity.
• Polyphenols decrease oxidative/nitrosative stress associated with aging in rat cochlea.
• Polyphenols improve presbycusis or age-related hearing loss by decreasing oxidative/nitrosative stress in rat cochlea.

Age-related hearing loss (AHL) –presbycusis– is the number one neurodegenerative disorder and top communication deficit of our aged population. Experimental evidence suggests that mitochondrial dysfunction associated with reactive oxygen species (ROS) plays a central role in the aging process of cochlear cells. Dietary antioxidants, in particular polyphenols, have been found to be beneficial in protecting against the generation of ROS in various diseases associated with oxidative stress, such as cancer, neurodegenerative diseases and aging.ObjectivesThis study was designed to investigate the effects of polyphenols on AHL and to determine whether oxidative stress plays a role in the pathophysiology of AHL.MethodsSprague-Dawley rats (n = 100) were divided into five groups according to their age (3, 6, 12, 18 and 24 months old) and treated with 100 mg/kg/day body weight of polyphenols dissolved in tap water for half of the life of the animal. Auditory steady-state responses (ASSR) threshold shifts were measured before sacrificing the rats. Then, cochleae were harvested to measure total superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, reactive oxidative and nitrogen species levels, superoxide anions and nitrotyrosine levels.ResultsIncreased levels of ROS and RNS in cochlea observed with age decreases with polyphenol treatment. In addition, the activity of SOD and GPx enzymes in older rats recovered after the administration of polyphenols. Conclusion: The reduction in oxidative and nitrosative stress in the presence of polyphenols correlates with significant improvements in ASSR threshold shifts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 83, October 2016, Pages 31–36
نویسندگان
, , , , ,
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
سفارش ترجمه تخصصی
با تضمین قیمت و کیفیت