The Role of Mitochondria in Drosophila Aging

►Long history of correlative studies on mitochondria and aging. ►Drosophila genetics can address causal relationships. ►Genes important for mitochondrial function have been shown to modulate fly longevity. ►Mitochondrial respiration important for diet restriction-mediated longevity. ►Transkingdom gene therapy can enhance mitochondrial activity and lifespan.