The effect of α-actinin-3 deficiency on muscle aging

►Loss of Actn3 genotype effect on intrinsic exercise performance with age. ►“Slower” fast muscle characteristics maintained in aged α-actinin-3 deficient mice. ►Lower grip strength in aged α-actinin-3 deficient mice compared to wild-type. ►Loss of Actn3 genotype effect on muscle mass in aged male mice. ►Muscle mass decline was greater in aged α-actinin-3 deficient mice.