کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10746017 | 1048746 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea
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کلمات کلیدی
5-HT5-hydroxytryptamine (serotonin) - 5-hydroxytryptamine (سروتونین)l-3,4-dihydroxyphenylalanine - L-3،4-دی هیدروکسی فنیل آلانینl-DOPA - L-DOPAmovement disorders - اختلالات حرکتیNeurodegenerative disorders - اختلالات نوروژنیکHuntington’s disease - بیماری هانتینگتونParkinson’s disease - بیماری پارکینسونtyrosine hydroxylase - تیروزین هیدروکسیلازlateral - جانبیDopamine - دوپامینSERT - سختserotonin transporter - سروتونین حمل کنندهdorsal - عقبbasal ganglia - عقدههای قاعدهایPUT - قرار دادنcaudate nucleus - هسته دم دارPutamen - پوسته، پوتامنinternal capsule - کپسول داخلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
In contrast to our vast knowledge of the dopamine (DA) system, much less is known about the involvement of serotonin (5-HT) in neurodegenerative diseases affecting the basal ganglia. Therefore, we designed a study that aimed at characterizing the status of the striatal DA and 5-HT systems in patients who suffered from either Parkinson's (PD) or Huntington's disease (HD), compared to age-matched controls. Antibodies against tyrosine hydroxylase (TH) and 5-HT transporter (SERT) were used as markers of DA and 5-HT axonal profiles, respectively. The density and pattern of TH+ and SERTÂ +Â innervation were determined by optical density measurements as well as by direct stereological estimates of labeled axon varicosities. The results reveal a significant decrease in TH immunoreactivity and THÂ +Â axon terminals throughout the striatum in both PD and HD, whereas the intensity of SERT immunostaining and the density of SERTÂ +Â axon varicosities were found to be slightly increased in the striatum of PD and HD patients compared to controls. These findings reveal that the nigrostriatal DA system is significantly impaired in both PD and HD compared to the striatal 5-HT innervation, which is slightly increased in these two conditions. The striatal 5-HT augmentation observed in PD might be the result of a neural mechanism designed to compensate for DA denervation, whereas the marked atrophy of the striatum might explain the increase in the 5-HT innervation noted in HD. These findings underline the importance of the complex interplay between DA and 5-HT striatal afferents in the elaboration of appropriate motor behaviour.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 17, Issue 8, September 2011, Pages 593-598
Journal: Parkinsonism & Related Disorders - Volume 17, Issue 8, September 2011, Pages 593-598
نویسندگان
Catherine Bédard, Marie-Josée Wallman, Emmanuelle Pourcher, Peter V. Gould, André Parent, Martin Parent,