کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10747169 | 1048894 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glial activation with concurrent up-regulation of inflammatory mediators in trimethyltin-induced neurotoxicity in mice
ترجمه فارسی عنوان
فعال سازی گلیال با تنظیم مجدد همزمان واسطه های التهابی در عصبی ناشی از ترتیب اتیلینین در موش
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کلمات کلیدی
تریمتیلین، هیپوکامپ، عصب خونی فعال سازی گلیال، سیتوکین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Trimethyltin (TMT), a potent neurotoxic chemical, causes dysfunction and neuroinflammation in the brain, particularly in the hippocampus. The present study assessed TMT-induced glial cell activation and inflammatory cytokine alterations in the mouse hippocampus, BV-2 microglia, and primary cultured astrocytes. In the mouse hippocampus, TMT treatment significantly increased the expression of glial cell markers, including the microglial marker ionized calcium-binding adapter molecule 1 and the astroglial marker glial fibrillary acidic protein. The expression of M1 and M2 microglial markers (inducible nitric oxide synthase [iNOS] and CD206, respectively) and pro-inflammatory cytokines (interleukin [IL]-1β, IL-6 and tumor necrosis factor [TNF]-α) were significantly increased in the mouse hippocampus following TMT treatment. In BV-2 microglia, iNOS, IL-1β, TNF-α, and IL-6 expression increased significantly, whereas arginase-1 and CD206 expression decreased significantly after TMT treatment in a time- and concentration-dependent manner. In primary cultured astrocytes, iNOS, arginase-1, IL-1β, TNF-α, and IL-6 expression increased significantly, whereas IL-10 expression decreased significantly after TMT treatment in a time- and concentration-dependent manner. These results indicate that significant up-regulation of pro-inflammatory signals in TMT-induced neurotoxicity may be associated with pathological processing of TMT-induced neurodegeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 116, Issue 8, October 2014, Pages 1490-1500
Journal: Acta Histochemica - Volume 116, Issue 8, October 2014, Pages 1490-1500
نویسندگان
Juhwan Kim, Miyoung Yang, Yeonghoon Son, Hyosun Jang, Dongwoo Kim, Jong-Choon Kim, Sung-Ho Kim, Man-Jong Kang, Heh-In Im, Taekyun Shin, Changjong Moon,