کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10766 702 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture
چکیده انگلیسی

Recently [Jessel N, Schwinte P, Donohue R, Lavalle P, Boulmedais F, Darcy R, et al. Pyridylamino-β-cyclodextrin as a molecular chaperone for lipopolysaccharide embedded in a multilayered polyelectrolyte architecture. Adv Funct Mater 2004;14:963–9], we demonstrated the biological activity of a lipopolysaccharide from Escherichia coli incorporated into layer-by-layer films made of poly (l-lysine) and poly (l-glutamic acid) and containing a polycationic β-cyclodextrin (CD) with chaperone properties. Here we develop innovative architectures containing a complex made of a charged β-cyclodextrin and a lipid A antagonist (LAA) as potential systems for local endotoxin antagonistic activity. We examine the biological activity of these architectures. The CD–LAA complex adsorbed on top, or embedded into the polyelectrolyte films keeps its LPS antagonistic activity on both murine and human macrophages for at least 24 h.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 27, Issue 9, March 2006, Pages 1771–1777
نویسندگان
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