کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10768 702 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Surface functionalization of degradable polymers by covalent grafting
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Surface functionalization of degradable polymers by covalent grafting
چکیده انگلیسی

With a new non-destructive and solvent-free photografting technique, N-vinylpyrrolidone was covalently grafted onto the surfaces of degradable polymers; poly(l-lactide), poly(ε-caprolactone), poly(lactide-co-glycolide), and poly(trimethylene carbonate). The modified surfaces were characterized by XPS, ATR-FTIR, SEM, and cell growth tests. The wettability was markedly improved, as static contact angles changed from about 80° for the pristine substrates to around 30° after 30 min of grafting. Well-defined surface topographies, such as micro-patterns, are preserved in the process since the graft layers are thin. The biological response, measured as cytotoxicity, showed that the modified films provide good substrates, comparable with optimized cell culture plastics, for the adhesion and proliferation of normal human keratinocytes and skin fibroblasts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 27, Issue 9, March 2006, Pages 1788–1796
نویسندگان
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