کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10818898 | 1060272 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
trans-Resveratrol and ε-viniferin decrease glucose absorption in porcine jejunum and ileum in vitro
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: trans-Resveratrol and ε-viniferin decrease glucose absorption in porcine jejunum and ileum in vitro trans-Resveratrol and ε-viniferin decrease glucose absorption in porcine jejunum and ileum in vitro](/preview/png/10818898.png)
چکیده انگلیسی
trans-Resveratrol and ε-viniferin are used as dietary supplements. They are reported to be supportive in preventing arteriosclerosis and diabetes and a previous study could demonstrate an inhibitory potential on sodium-dependent glucose transport (SGLT1) in oocytes und mouse intestinal everted rings (Schulze et al., 2012, Genes Nutr. 6, S61). The in vitro effects of trans-resveratrol and ε-viniferin on intestinal glucose uptake in the porcine small intestines (Sus Scrofa) have not yet been evaluated. It was hypothesized that trans-resveratrol/ε-viniferin may have an adverse effect on porcine intestinal sodium-dependent glucose uptake. The effects on electrogenic small intestinal glucose absorption and sodium-dependent 3H-glucose uptake in brush border membrane vesicles (BBMV) were evaluated. Pieces of mucosa were mounted into Ussing chambers and were incubated with either trans-resveratrol (0.3 mmol/L), ε-viniferin (0.3 mmol/L), or ethanol. Sodium-dependent glucose absorption into BBMV was measured. 3H-glucose uptake studies were performed using the same concentrations of the respective substances. SGLT1-mediated glucose absorption was approximately 3-fold higher in ileum compared to jejunum. After preincubation with trans-resveratrol and ε-viniferin, glucose-induced increases of short-circuit currents were significantly decreased. BBMV-studies revealed comparable results and glucose uptake was also significantly decreased. As the glucose transport/uptake was decreased after preincubation with either trans-resveratrol or ε-viniferin this active transport mechanism was directly influenced by inhibiting the SGLT1 transport system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 165, Issue 3, July 2013, Pages 313-318
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 165, Issue 3, July 2013, Pages 313-318
نویسندگان
Maria Guschlbauer, Stefanie Klinger, Marion Burmester, Jana Horn, Sabine E. Kulling, Gerhard Breves,