کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10822014 | 1061561 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polyamine transport in parasites: A potential target for new antiparasitic drug development
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کلمات کلیدی
S-adenosylhomocysteineOrnithine decarboxylaseα-DifluoromethylornithineTrichomonasS-adenosylmethionine decarboxylase - S-adenosylmethionine dearboxylasearginine decarboxylase - آرژینین دکربوکسیلازS-adenosylmethionine - اس-ادنوزیل متیونینSpermidine/spermine N1-acetyltransferase - اسپرمیدین / اسپرمین N1-استیل ترانسفرازSleeping sickness - بیماری خوابTrypanosoma - تریپانوزوما، مته تنChagas disease - شاگاسLeishmania - لیشمانیا ATP binding cassette - کیت اتصال ATP
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The metabolism of the naturally occurring polyamines-putrescine, spermidine and spermine-is a highly integrated system involving biosynthesis, uptake, degradation and interconversion. Metabolic differences in polyamine metabolism have long been considered to be a potential target to arrest proliferative processes ranging from cancer to microbial and parasitic diseases. Despite the early success of polyamine inhibitors such as alpha-difluoromethylornithine (DFMO) in treating the latter stages of African sleeping sickness, in which the central nervous system is affected, they proved to be ineffective in checking other major diseases caused by parasitic protozoa, such as Chagas' disease, leishmaniasis or malaria. In the use and design of new polyamine-based inhibitors, account must be taken of the presence of up-regulated polyamine transporters in the plasma membrane of the infectious agent that are able to circumvent the effect of the drug by providing the parasite with polyamines from the host. This review contains information on the polyamine requirements and molecular, biochemical and genetic characterization of different transport mechanisms in the parasitic agents responsible for a number of the deadly diseases that afflict underdeveloped and developing countries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 140, Issue 2, February 2005, Pages 151-164
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 140, Issue 2, February 2005, Pages 151-164
نویسندگان
Rosa MarÃa Reguera, Babu L. Tekwani, Rafael Balaña-Fouce,