Neuropsin-A possible modulator of synaptic plasticity

► Current studies have suggested pivotal roles for neural proteases in development, maturation, aging, and cognition. ► In the present review article, possible neural function of neuropsin, a serine protease, was focused, and importance in early phase of LTP was descried. ► The involvement of neuropsin in the single synaptic function leads to relate to synaptic late association between two independent hippocampal synapses. ► This hypothetical synaptic associations may be related to mammalian working memory and consequently integration in learning and memory.