Alteration of the CNS pathway to the hippocampus in a mouse model of Niemann-Pick, type C disease

► Neurons in CA2&3 regions of the hippocampus decreased dramatically in the NPC−/− mouse. ► Pseudorabies virus positive cell number in CNS hippocampal pathway significantly decreased. ► Changes in the CNS hippocampal pathway may contribute to symptoms of Niemann-Pick disease, type C.