کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10825303 | 1063590 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Correlation between dopaminergic neurons, acetylcholinesterase and nicotinic acetylcholine receptors containing the α3- or α5-subunit in the rat substantia nigra
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کلمات کلیدی
SNCfluorescein isothiocyanate conjugateTRITCVTAnAChRSNRFITCAChE - آهیAcetylcholinesterase - استیل کولین استرازsubstantia nigra - توده سیاهsubstantia nigra pars compacta - توده سیاه پارس متراکمTexas red - تگزاس قرمزtyrosine hydroxylase - تیروزین هیدروکسیلازPPN - مالیات بر ارزش افزودهventral tegmental area - ناحیه تگمنتوم شکمیpedunculopontine tegmental nucleus - هسته تمثالی pedunculopontinenicotinic acetylcholine receptor - گیرنده استیلکولین نیکوتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to investigate the relationship between the cells possessing the α3 or α5 nicotinic acetylcholine receptor subunits and the enzyme acetylcholinesterase, with respect to tyrosine hydroxylase immunoreactive dopaminergic neurons in the rat substantia nigra. Most, but certainly not all, acetylcholinesterase immunoreactive cells were located in the pars compacta. In the substantia nigra pars compacta there were in turn two populations of acetylcholinesterase containing neurons: those that were tyrosine hydroxylase reactive and those that were not. Double label studies, that included an antibody immunoreactive against a common immunogen on α1 of muscle and α3 and α5 neuronal nicotinic acetylcholine receptor subunits, revealed that nearly all nicotinic receptor positive cells were also tyrosine hydroxylase neurons. However, a minority non-tyrosine hydroxylase population was α3- and/or α5-nAChR positive and these were always AChE-immunoreactive. In summary, there appears to be a close correlation between nicotinic receptors and acetylcholinesterase in the substantia nigra, irrespective of the transmitter phenotype in different neuronal subpopulations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chemical Neuroanatomy - Volume 30, Issue 1, July 2005, Pages 34-44
Journal: Journal of Chemical Neuroanatomy - Volume 30, Issue 1, July 2005, Pages 34-44
نویسندگان
Stevan R. Emmett, Susan A. Greenfield,