Rapid modulation of TRH and TRH-like peptide release in rat brain and peripheral tissues by ghrelin and 3-TRP-ghrelin

► Ghrelin stimulates TRH-like peptide release in brain and peripheral tissues. ► 3-Trp-ghrelin inhibits TRH-like peptide release in brain and peripheral tissues. ► TRH-like peptides mediate opposing effects of aceylated and unacylated ghrelin.