Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA)

► Peptidomic analysis of skin secretions of the tetraploid frog Silurana epitropicalis has led to characterization of 10 antimicrobial peptides of the magainin, PGLa, CPF, and XPF families. ► Nonfunctionalization of antimicrobial peptides genes has occurred following polyploidization in the Siluran lineage. ► CPF-SE2 and CPF-SE3 show therapeutic potential for treatment of MRSA skin infections.