Host-defense peptides of Australian anurans. Part 2. Structure, activity, mechanism of action, and evolutionary significance

► Use of e.g. NMR and QCM-D methods to determine how membrane-active peptides destroy cell membranes. ► Anuran peptides which form complexes with Ca2+ CaM resulting in deactivation of nNOS. ► Divergent structures of neuropeptides including smooth-muscle agents, opioids and immunomodulators. ► cDNA sequences of pre-pro-peptides from dorsal glands of anurans provide evolutionary data.