Effect of intranasal arginine vasopressin on human headache

► Arginine vasopressin (AVP) concentration in both plasma and cerebrospinal fluid (CSF) increased in human headache patients, which related with headache level. ► There was a positive relationship between plasma and CSF AVP concentration in human headache patients. ► Intranasal AVP could relieve the human headache in a dose-dependent manner. ► Intranasal AVP could treat human headache and AVP might be potential drug of pain relief.