Identification of orexins and cognate receptors in the lacrimal gland of sheep

► The orexinergic system is expressed in the lacrimal gland of sheep. ► OX1R transcript is two-fold higher than OX2R. ► Positive staining for OX1R is evidenced in the wall of small arteries. ► OX2R staining is localized in the secretory portion of the acinar gland cells. ► The orexinergic system might regulate the lacrimal gland function.