Keywords: Neural circuits; Reinstatement; Self-administration; Ventral pallidum; Voluntary abstinence; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BLA; basolateral amygdala; BNST; bed nucleus of the stria terminalis; CeA; central amygdala nucleus;
مقالات ISI (ترجمه نشده)
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Keywords: Diabetes; OX1R; Testis; Steroidogenesis; Glucose homeostasis;
Identification of highly selective and potent orexin receptor 1 antagonists derived from a dual orexin receptor 1/2 antagonist based on the structural framework of pyrazoylethylbenzamide
Keywords: OX1R; orexin 1 receptor; OX2R; orexin 2 receptor; DORA; dual orexin receptor antagonist; SORA; selective orexin receptor antagonist; SI; selectivity index; BBB; blood-brain barrier; CNS; central nervous system; SAR; structure-activity relationship; Boc; t
Keywords: Hypocretin; Ox1R; Ox2R; Blood pressure; Heart rate; Sympathetic; Hypothalamus; Perifornical area; Rostral ventrolateral medulla; Psychological stress; SHR; Schlager mouse;
Keywords: AC; anterior cingulate cortex; BA; brodman area; BDA; biotinylated dextran amine; DAB; diaminobenzidine; HRP; horseradish peroxidase; IL; infralimbic cortex; LH; lateral hypothalamus; mPFC; medial prefrontal cortex; OX1R; type 1 orexin receptor; PBS; phos
Keywords: PA; palmitic acid; TNF-α; tumor necrosis factor alpha; NFκB; nuclear factor-kappa B; OXA; orexin A/hypocretin 1; OX1R; orexin receptor 1; OX2R; orexin receptor 2; IL-6; interleukin 6; LPS; lipopolysaccharide; TLR-4; toll like receptor 4; RT-PCR; real ti
Keywords: Hypocretin; Stress; Blood pressure; Heart rate; SORA; DORA; ChAT; Choline acetyl transferase; ÎHR; relative change in heart rate; ÎMAP; relative change in mean blood pressure; DORA; dual orexin receptor antagonist; HR; heart rate; MAP; mean blood pressu
Keywords: EEG; electroencephalogram; EMG; electromyogram; EOG; electrooculogram; LC; locus coeruleus; LDT/PPT; latero dorsal tegmentum/pedunculo pontine tegmentum; NA; noradrenalin; NREMS; non-REMS; OX; orexin; OX1R; orexin receptor1; PeF; perifornical area; PS; po
Keywords: CFA; complete Freund's adjuvant; DORA-12; dual orexin receptor antagonist; OX1R; orexin receptor 1; PKA; protein kinase A; SORAs; single orexin receptor antagonists; STN; spinal trigeminal nucleus; TMJ; temporomandibular joint; TPGS; tocopheryl polyethy
Keywords: AC; adenylyl cyclase; BAT; brown adipose tissue; BMP; bone morphogenetic protein; BST; bed nucleus of the stria terminalis; CB1R; cannabinoid receptor type 1; CNS; central nervous system; CREB; cAMP-response element binding protein; DRN; dorsal raphe nucl
A comparison of the orexin receptor distribution in the brain between diurnal Nile grass rats (Arvicanthis niloticus) and nocturnal mice (Mus musculus)
Keywords: Orexin; Hypocretin; Chronotype; OX1R; OX2R;
Increased training compensates for OX1R blockage-impairment of spatial memory and c-Fos expression in different cortical and subcortical areas
Keywords: OX1R; orexin-A selective receptor; HPC; hippocampus; RSC; retrosplenial cortex (g-granular d-dysgranular); IL; infralimbic cortex; PL; prelimbic cortex; mPFC; medial prefrontal cortex; Re; reuniens; Rh; rhomboid; AD; anterodorsal; CL; centrolateral; CM; c
Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina
Keywords: Orexin; Retinal rod bipolar cell; GABA receptor; Neuromodulation; BCs; bipolar cells; BIC; bicuculline; Bis-IV; bisindolylmaleimide IV; CPPG; (RS)-α-cyclopropyl-4-phosphor- nophenylalycine; DAG; diacylglycerol; DLG; dorsal lateral geniculate nucleus; DT-
Chronopathophysiological implications of orexin in sleep disturbances and lifestyle-related disorders
Keywords: Aβ; amyloid β; AI; androgeno-independent; BAT; brown adipose tissue; BNST; bed nucleus of the stria terminalis; CeA; central nucleus of amygdala; CSF; cerebrospinal fluid; DMNV; dorsal motor nucleus of the vagus; DORA; dual orexin receptor antagonist; D
Localization and expression of Orexin A and its receptor in mouse testis during different stages of postnatal development
Keywords: Orexin A; OX1R; Postnatal development; Testis; Mouse;
Research articleAntagonism of orexin type-1 receptors (OX1Rs) attenuates naloxone-precipitated morphine withdrawal syndrome in rat dorsal hippocampus
Keywords: aCSF; artificial cerebrospinal fluid; cAMP; cyclic adenosine monophosphate; CREB; cAMP response element-binding protein; DMSO; dimethyl sulfoxide; LC; locus coeruleus; NMDA; N-methyl-d-aspartate; OX1R; orexin type-1 receptor; OX2R; orexin type-2 receptor;
Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling
Keywords: MRAP1/2; melanocortin accessory receptor 1/2; GPCR; G-protein coupled receptor; PKR 1/2; prokineticin receptor 1/2; OX1R; orexin receptor 1; MC2/4R; melanocortin-2/4 receptor; CHO; Chinese hamster ovary; YFP; yellow fluorescent protein; ALP; alkaline phos
The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism
Keywords: GPCR; G protein-coupled receptor; OX1R; orexin 1 receptor; KOR; kappa opioid receptor; JNK; c-Jun N-terminal kinase; cAMP; cyclic adenosine monophosphate; VTA; ventral tegmental area; CHO; Chinese hamster ovary; FLIPR; fluorescence in situ plate reader; P
REM sleep modulation by perifornical orexinergic inputs to the pedunculo-pontine tegmental neurons in rats
Keywords: EEG; electroencephalogram; EMG; electromyogram; EOG; electrooculogram; LC; locus coeruleus; NREMS; non-REMS; Ox; orexin; OX1R; orexin receptor1; PeF; perifornical area; PPT; pedunculo-pontine tegmentum; REMS; rapid eye movement sleep; REMSD; REMS deprivat
Heterodimerization of human orexin receptor 1 and kappa opioid receptor promotes protein kinase A/cAMP-response element binding protein signaling via a Gαs-mediated mechanism
Keywords: GPCR; G-protein-coupled receptor; OX1R; orexin (hypocretin) receptor 1; KOR; kappa opioid receptor; BRET; bioluminescence resonance energy transfer; FRET; fluorescence resonance energy transfer; CREB; cAMP-response element binding protein; PKA; protein ki
Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats
Keywords: Hypothalamus; Sympathetic nerve activity; Obesity; Orexin receptors; PVN; paraventricular nucleus; ABP; arterial blood pressure; RSNA; renal sympathetic nerve activity; OZRs; obese Zucker rats; LZRs; lean Zucker rats; OX1R; Orexin receptor 1; OX2R; Orexin
Orexin-A-induced ERK1/2 activation reverses impaired spatial learning and memory in pentylenetetrazol-kindled rats via OX1R-mediated hippocampal neurogenesis
Keywords: Epilepsy; Orexin-A; Learning and memory; OX1R; ERK1/2; Neurogenesis
Design, synthesis, and structure-activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists
Keywords: OX1R; orexin 1 receptor; OX2R; orexin 2 receptor; THF; tetrahydrofuran; TBDPS; tert-butyldiphenylsilyl; DMF; N,N-dimethylformamide; DIAD; diisopropyl azodicarboxylate; TBAF; tetra-n-butylammonium fluoride; DMSO; dimethyl sulfoxide; TEA; triethylamine; DCM
Orexin-1 receptor mediates the increased food and water intake induced by intracerebroventricular injection of the stable somatostatin pan-agonist, ODT8-SST in rats
Keywords: DMSO; dimethylsulfoxide; icv; intracerebroventricular(ly); LHA; lateral hypothalamic area; NPY; neuropeptide Y; OX1R; orexin-1 receptor; OX2R; orexin-2 receptor; sst; somatostatin receptor; Food intake; Orexin-A; ODT8-SST; SB-334867; Somatostatin 2 recept
Orexin system expression in the gastrointestinal tract of pigs
Keywords: OXA; OXB; OX1R; OX2R; Ghrelin; Gastrin
Immunohistochemical detection of the orexin system in the placenta of cats
Keywords: OXA; OX1R; OX2R; Immunohistochemistry; Decidua; Cat
Orexins promote survival of rat cortical neurons
Keywords: CNS; central nervous system; GFAP; glial fibrillary acidic protein; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium; OX1R; orexin type 1 receptor; OX2R; orexin type 2 receptor; Orexin; Hypocretin; Cell viability; Caspase-3; Neurons; Neuropro
Identification of orexins and cognate receptors in the lacrimal gland of sheep
Keywords: Orexin/hypocretin; OXA; OXB; PPOX; OX1R; OX2R;
Differential gene expression and immune localization of the orexin system in the major salivary glands of pigs
Keywords: OXA; OXB; PPOX; OX1R; OX2R; Mandibular gland;
Aging-related alterations in orexin/hypocretin modulation of septo-hippocampal amino acid neurotransmission
Keywords: aging; hippocampus; hypocretin; microdialysis; orexin; medial septum; aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; CA1; cornu ammonis 1; GAD67; glutamic acid decarboxylase 67; LTP; long-term potentiation; OxA; orexin A; Ox1R; orexin
Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1
Keywords: Appetite; Rimonabant; Orexin A-hypocretin 1; CB1; OX1R; Wistar;
Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats
Keywords: Neural basis of behavior; Biological rhythms and sleep; ICV; intracerebroventricular; REM; rapid eye movement; non-REM; non-srapid eye movement; LHA; lateral hypothalamic area; OX1R; orexin receptor type 1; OX2R; orexin receptor type 2; LC; locus coeruleu